Bone marrow is a reservoir of functionally potent VZV-reactive memory CD4⁺ T cells (IMAGE)
Caption
(A) Schematic overview of the experimental workflow. (B) Representative flow cytometry plots showing IL-2⁺, TNF-α⁺, and IFN-γ⁺ expressions of VZV-reactive CD4⁺CD45RO⁺CD154⁺ memory T cells, (C–D) Absolute numbers of VZV-reactive CD4⁺CD45RO⁺CD154⁺ memory T cells (C) and total cytokines (D) producing cells were significantly higher in BM than PB. (E) Absolute total counts of separate IL-2⁺, IFN-γ⁺, and TNF-α⁺ in VZV-reactive CD4⁺ memory T cells. (F) Absolute numbers of single, double, and triple cytokine-producing CD4⁺CD154⁺ memory T cells in PB and BM, categorized by cytokine expression (IFN-γ⁺, IL-2⁺, and TNF-α⁺). (G) Absolute numbers of polyfunctional CD4⁺CD154⁺Cyt⁺ T cells in PB and BM, defined as the sum of double and triple cytokine-producing cells.
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