MMP12 exacerbates pulmonary inflammation by enhancing IL-17A expression (IMAGE)

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MMP12 exacerbates pulmonary inflammation by enhancing IL-17A expression

Caption

M. pneumoniae CARDS toxin triggers respiratory epithelial apoptosis; cell debris is then recognized by macrophages, inducing MMP12 production. Subsequently, Mmp12high macrophages communicate with Th17 cells via Spp1 and Fn1, boosting IL-17A production and contributing to alveolar damage and chronic inflammation.

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hLife

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