Harmonic Output of Stromal Traits Factor (HOST-Factor), a composite score integrating multiple function-informing stromal biomarkers. (IMAGE)

Temple University Health System

Harmonic Output of Stromal Traits Factor (HOST-Factor), a composite score integrating multiple function-informing stromal biomarkers.

Caption

HOST-Factor levels indicate Gem-PLDR induces a supportive-to-restrictive CAFu-generated ECM transition. (A) Graph of HOST-Factor values calculated from the 5 phenotypic assays ( Figures 3–5 ). Zero represents the population mean across all samples and conditions; positive values indicate a supportive CAFu phenotype; negative values indicate reduced support or a supportive-to-restrictive transition. Data are means ± standard error of the mean of combined Z-scores, each weighted as one-fifth of the total (see Supplementary Table “Statistical Data” details). EN = 4. (B) Schematic illustrating the individual tendencies of the measured phenotypic tests comprising the HOST-Factor.

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Gastro Hep Advances Vol. 5Issue 4

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