Association of epigenetic age acceleration with MRI biomarkers of aging and Alzheimer’s disease neurodegeneration (IMAGE)
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Figure 5. Associations of DNAm SmokingPackYears from AgeAccelGrim2 with global and regional brain volumes (in cm3) from linear regression models adjusting for chronological age, hormone therapy trial arm, education, smoking status, race, ethnicity, physical activity, BMI, diabetes, cardiovascular disease, cancer, blood cell composition, and intracranial volume. Beta coefficients are reported for each 1 standard deviation increase in the epigenetic measure.
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Copyright: © 2026 McEvoy et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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