How to remove a metabolic tattoo (IMAGE)
Caption
Past exposure to metabolic stress can be “tattooed” on CD8+ T cells, inducing a lasting vulnerability to an iron-dependent form of cell death known as ferroptosis, particularly in the tumor context., Metabolic tattooing of CD8+ T cells can potentially be reversed by activating the purine salvage pathway, metabolizing xanthine to GTP and the anti-oxidant BH4, recovering anti-tumor activity.
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KyotoU / Masaki Tajima
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