Figure (IMAGE)

Ben-Gurion University of the Negev

Figure

Caption

Sir-2.4 KO deteriorates proteostasis in C. elegans. (A) Heat shock resistance assay, measuring the paralysis rate after a heat shock in days 1 and 2 of adulthood, followed by an overnight recovery period. (B) Motility rate assay, measuring the aging progression in days 1, 3, 5 of adulthood, both in the basal strains (N2/sir-2.4KO) and the Q40n-crossed strains. ####p < 0.0001 between N2/sir-2.4KO strains; *p < 0.05 between the Q40n-crossed strains. (C) Motility assay with 1.65mM 4-PBA from L4 stage to day 1 of adulthood. (D) Survival assay data for all C. elegans strains. (E, F) selected individual strains and treatments, separated for clarity. ns–p > 0.05, *p < 0.05, **p < 0.005, ****p < 0.0001.

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Prof. Debra Toiber

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