GO enrichment analysis and KEGG pathway analysis of co-expressed mRNA targets in the NC and EIU groups (IMAGE)

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GO enrichment analysis and KEGG pathway analysis of co-expressed mRNA targets in the NC and EIU groups

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(A–C) GO enrichment analysis of co-expressed mRNA targets, covering biological processes, cellular components, and molecular functions. The top 10 GO terms of each domain are shown. (D) The top 10 enriched KEGG terms. (E) Real-time PCR was used to quantify the number of miDNA copies in the cytoplasm. The released mtDNA was significantly increased at 24 h and 48 h in the EIU groups. ∗∗P < 0.01. n = 3 biological replicates in each group. (F) GSEA snapshots of cytosolic DNA-sensing pathway enrichment analysis. (G) Hierarchical clustering heatmap analysis of cytosolic DNA-sensing pathway mRNAs. (H) The cGAS-STING-TF-inflammatory network. NC, normal control; EIU, endotoxin-induced uveitis; GSEA, gene set enrichment analysis; GO, gene ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; cGAS, cyclic guanosine monophosphate-adenosine monophosphate synthase; STING, stimulator of interferon genes; TF, transcription factor.

Credit

Yue Guo, Ruiping Gu, Jiaojiao Wei, Chunhui Jiang

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