Schematic of the oral HOF-based nanoreactor for treating age-related cognitive decline through gut metabolic reprogramming (IMAGE)

Science China Press

Schematic of the oral HOF-based nanoreactor for treating age-related cognitive decline through gut metabolic reprogramming

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(a) The construction process of the MAO@NADH@PB@O-HOF@PEG nanoreactor, illustrating the encapsulation of MAO, NADH, and PB within the HOF, followed by PEGylation. (b) The in vivo therapeutic mechanism showing the nanoreactor surviving the gastrointestinal tract to reduce reactive oxygen species (ROS) and deplete the aging-related metabolite isoamylamine (IAA) in the gut. (c) The overall therapeutic outcomes demonstrating that the nanoreactor prevents IAA circulation to the central nervous system, thereby rescuing cognitive decline, microglial apoptosis, and neuronal damage associated with aging.

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