Distinct immune pathways separate vaccine protection from reactogenicity (IMAGE)

The Institute of Medical Science, The University of Tokyo

Distinct immune pathways separate vaccine protection from reactogenicity

Caption

Schematic representation showing how squalene-based adjuvants activate distinct immune pathways: IL-1β drives protective immunity, while IL-1α from eosinophils causes local swelling and IL-6/COX2 pathways lead to fever.

Credit

Prof. Ken J. Ishii from The University of Tokyo, Japan

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