Advantages and challenges of LNP–mRNA delivery systems for engineered cell therapy (IMAGE)

Xia & He Publishing Inc.

Advantages and challenges of LNP–mRNA delivery systems for engineered cell therapy

Caption

Created with Figdraw. LNP-based mRNA delivery enables safe, transient, and controllable protein expression with rapid kinetics and scalable production. However, challenges include immunogenicity, manufacturing complexity, and limited clinical validation. Promising applications include CAR-T cell engineering and ligand-directed targeting within the tumor microenvironment (TME). CAR, chimeric antigen receptor; LNP, Lipid Nanoparticles; mRNA, messenger RNA.

Credit

Ying Liu

Usage Restrictions

Credit must be given to the creator. Only noncommercial uses of the work are permitted.

License

CC BY-NC

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.