Figure (a) (IMAGE)

National University of Singapore

Figure (a)

Caption

Figure (a) shows the formation of a DNA tether between the bead and the engineered Piezo1 channel, along with the remote suction setup used to apply force. Figure (b) illustrates the design of the engineered Piezo1 construct and the DNA-based force transduction system. A calcium ion (Ca2+) reporter is fused to the C-terminus to monitor channel activity via fluorescence, while DNA-coated beads are attached to the channel to enable targeted mechanical stimulation.

Credit

Nature Sensors

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