PCGF1 safeguards early lineage specification by coordinating chromatin regulators to balance pluripotency repression and developmental gene activation. (IMAGE)
Caption
PCGF1, an essential component of the PRC1.1 complex, preferentially associates with active and bivalent developmental loci. Its absence leads to defective gastrulation and hinders differentiation of mouse embryonic stem cells in vitro, marked by insufficient silencing of pluripotency programs and inappropriate activation of lineage-specific genes. At the mechanistic level, PRC1.1 collaborates with PRC2, MLL2, and UTX to shape a chromatin landscape that supports dynamic regulation of H3K27me3, thereby ensuring accurate control of gene expression during the earliest stages of lineage commitment.
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Pan Chen
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