AFM & Cryo-EM images (IMAGE)

Medical Research Council (MRC) Laboratory of Medical Sciences

AFM & Cryo-EM images

Caption

Left panels: Atomic Force Microscopy images show how circular DNA can shift from a relaxed shape into a tightly twisted form, and how the gene-editing protein Cas9 binds to this coiled DNA (Credit: University of Sheffield). Right panels: High-resolution Cryo-electron microscopy structure showing Cas9 locked onto the twisted DNA mini-circle (Credit: MRC Laboratory of Medical Sciences).

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University of Sheffield and MRC Laboratory of Medical Sciences

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