Taking pressure off the lungs (IMAGE)
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Proposed role of CNP/GC-B signaling in PAH.
In PAH, expression of CNP and its receptor GC-B is reduced in the pulmonary vasculature. Endothelial cell-specific CNP or GC-B knockout mice, but not smooth muscle cell-specific GC-B knockout mice, showed more severe PH in mice. Administration of CNP activates endothelial GC-B signaling, which suppresses endothelin-1, inflammatory cytokines, and SMAD imbalance, thereby attenuating pulmonary vascular remodeling and disease progression.
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KyotoU / Hiromu Yanagisawa
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