Methionine oxidation and stereochemistry in the antibody Fc region (IMAGE)

National Institutes of Natural Sciences

Methionine oxidation and stereochemistry in the antibody Fc region

Caption

Structural environments of the methionine residues M252 (green) and M428 (blue) in the Fc region are shown. Upon oxidation, these residues are converted to methionine sulfoxide, generating two stereoisomeric forms with different spatial configurations (the S and R isomers).

Credit

Maho Yagi-Utsumi, Koichi Kato

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License

CC BY

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