Adipocyte-derived extracellular vesicles are key regulators of central leptin sensitivity and energy homeostasis (IMAGE)

Nanjing University School of Life Sciences

Adipocyte-derived extracellular vesicles are key regulators of central leptin sensitivity and energy homeostasis

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The exact mechanisms underlying leptin resistance remain elusive. Here, Wang et al. report that adipocyte-derived EVs and their miRNA cargo are key regulators of central leptin sensitivity and that the loss of these leptin-sensitizing miRNAs in adipocyte EVs contributes to leptin resistance and obesity.

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