Model for regulation of cuproptosis by glycogen metabolism in macrophages (IMAGE)

Editorial Office of West China School of Stomatology, Sichuan University

Model for regulation of cuproptosis by glycogen metabolism in macrophages

Caption

Excessive intracellular copper, during inflammatory bone disorders including apical periodontitis, suppresses glycogen synthase 1 (GYS1) transcription, affecting glycogen synthesis and impacting macrophage survival. Reducing copper overload and restoring glycogen synthesis is a potential pathway for new therapies against these disorders.

Credit

Professor Lu Zhang from Wuhan University Image source link: https://www.nature.com/articles/s41368-025-00408-1#citeas

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