Dual-Targeted Hybrid Nanovesicles for Multimodal Diabetic Wound Healing. (IMAGE)
Caption
Dual-Targeted Hybrid Nanovesicles for Multimodal Diabetic Wound Healing. Schematic illustration of the design, targeting behavior, and therapeutic mechanisms of DFO-loaded hybrid extracellular vesicles (DFO@HEVs) in diabetic wound repair. Endothelial cell–derived vesicles and neutrophil-derived nanovesicles are fused by co-extrusion and ultrasonication, followed by deferoxamine loading to generate DFO@HEVs. After local injection, the hybrid vesicles achieve dual targeting by homing to endothelial cells via CXCR4 and to inflamed endothelium through β2 integrin–ICAM-1 interactions. In endothelial cells, DFO@HEVs activate the Nrf2–ARE pathway, enhance antioxidant defenses, and suppress ferroptosis. In macrophages, they inhibit NF-κB signaling, reduce pro-inflammatory cytokine production, promote M2 polarization, and enhance efferocytosis, collectively restoring a pro-healing wound microenvironment.
Credit
Burns & Trauma
Usage Restrictions
Credit must be given to the creator. Only noncommercial uses of the work are permitted.
License
CC BY-NC