The H3.3-CBX7-KAP1 axis: A new pathway for heterochromatin establishment (IMAGE)

Science China Press

The H3.3-CBX7-KAP1 axis: A new pathway for heterochromatin establishment

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Schematic diagram illustrating the novel epigenetic pathway. The dual modification on histone variant H3.3 recruits CBX7, which brings the scaffold protein KAP1 to chromatin. KAP1 facilitates H3K9me3 deposition, leading to stable heterochromatin formation essential for X-chromosome inactivation and retrotransposon silencing.

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