Loss of Angptl4 Protects Mice from Intestinal Colitis and Tumorigenesis with Alternative Activation of Macrophages (IMAGE)

Elsevier

Loss of Angptl4 Protects Mice from Intestinal Colitis and Tumorigenesis with Alternative Activation of Macrophages

Caption

A novel study in The American Journal of Pathology using a mouse model has found that the absence of the ANGPTL4 protein during development triggers a long-lasting reprogramming of the immune system that protects against intestinal inflammation. This illustration shows how normal, wild-type mice experience severe inflammation and tumor development (red zones, top). Angptl4 knockout (KO) mice are protected against inflammation via reprogrammed immune cells (macrophages, bottom).

Credit

The American Journal of Pathology / Yoo et al.)

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License

CC BY

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