Bidirectional Regulation between Metabolic Dysfunction-associated Steatotic Liver Disease and Sarcopenia via Liver-muscle Crosstalk (IMAGE)
Caption
By integrating MR analysis, complementary mouse models, and multi-tissue transcriptomics, we identified CCL2 and ADM as putative mediators of this inter-organ communication. These findings underscore the importance of viewing MASLD and sarcopenia as interconnected disorders, and targeting the hepatokine-myokine axis may break the vicious cycle that sustains both diseases. Future studies are needed to clarify the temporal sequence of sarcopenia onset and MASLD progression, and to further elucidate the downstream signaling pathways involving CCL2 and ADM.
Credit
Jian-Gao Fan, Cen Xie
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License
CC BY-NC