Establishment of the Immunotoxicity AOP Framework (IMAGE)
Caption
Establishment of the Immunotoxicity AOP Framework: The binding of PCP to TLR5 was identified as the molecular initiating event. This event triggers a series of key events, activation of the TLR signaling pathway, an enhanced inflammatory response, increased oxidative stress levels, disrupted amino acid metabolism, and liver injury, ultimately leading to impaired immune system function (adverse outcome).
Credit
Zhang, Y. et al
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CC BY-NC-ND