Apex1-mediated redox signaling regulates fracture healing (IMAGE)

Editorial Office of West China School of Stomatology, Sichuan University

Apex1-mediated redox signaling regulates fracture healing

Caption

Cellular and molecular role of Apex1 in fracture healing. (a) Apex1 regulates Bmp2 expression in mesenchymal progenitors during inflammation and promotes chondrocyte differentiation during repair. (b) Apex1 and thioredoxin (TXN) enable redox-dependent activation of transcription factors that drive Bmp2 expression and chondrocyte maturation, ensuring effective fracture healing.

Credit

Dr. Emma Muiños-López from Clínica Universidad de Navarra, Spain Image Source Link: https://doi.org/10.1038/s41413-025-00486-1

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License

CC BY

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