Circadian-Based Optimization of ICI Therapy (IMAGE)
Caption
ICI therapy can be optimized by leveraging circadian rhythms and tumor microenvironment characteristics through four main strategies: (1) Optimizing the timing of ICI administration to the early morning or active phases based on circadian patterns; (2) Combining therapies targeting key immune cells, receptors, and cytokines in the tumor microenvironment; (3) Implementing chronobiological interventions including small molecule agonists (RORγ, REV-ERBα/β, CRY), hormone modulation, and non-pharmacological approaches; (4) Personalizing treatment based on individual circadian profiles.
Credit
Anqi Lin, Xiuhui Fang, Bufu Tang, Peng Luo
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