Flowchart of the study design and analysis. (IMAGE)

Beijing Institute of Technology Press Co., Ltd

Flowchart of the study design and analysis.

Caption

Based on genome-wide association study (GWAS) summary statistics for schizophrenia and 5 DTI parameters of white matter, we conducted conditional and conjunctional false discovery rate (cond/conjFDR) analyses to identify genomic loci associated with schizophrenia and white matter microstructure, as well as loci shared between them. For the identified loci, locus-level analyses were performed, including functional annotation and gene mapping. Finally, gene-level analyses encompassed the following: enrichment analysis, spatiotemporal gene expression trajectory analysis, colocalization analysis, transcriptome-wide association study (TWAS), and drug–gene interaction analysis. eQTL, expression quantitative trait locus; ncRNA, noncoding RNA; PCW, postconceptional weeks; PY, postnatal years; SCZ, schizophrenia; UTR3, 3′ untranslated region; UTR5, 5′ untranslated region.

Credit

Yujie Zhang, Tianjin Medical University.

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