Preoperative VEGFR-TKI Plus ICI Therapy Facilitates 3D-Guided Cytoreductive Nephron-Sparing Surgical Feasibility and Immune Remodeling in Advanced Renal Cell Carcinoma (IMAGE)

FAR Publishing Limited

Preoperative VEGFR-TKI Plus ICI Therapy Facilitates 3D-Guided Cytoreductive Nephron-Sparing Surgical Feasibility and Immune Remodeling in Advanced Renal Cell Carcinoma

Caption

Preoperative VEGFR-TKI plus ICI therapy in advanced ccRCC normalizes tumor vasculature, enhances CD8⁺ T/B cell infiltration, and promotes TLS maturation, leading to profound tumor microenvironment remodeling. These immunologic changes improve the feasibility of 3D reconstruction-guided robotic cytoreductive nephron-sparing surgery, resulting in reduced blood loss, fewer complications, preserved renal function, and prolonged survival.

Credit

Wenhao Xu

Usage Restrictions

None

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.