Schematic diagram showing how HBP regulates exosome release by modulating the O-GlcNAcylation of SNAP25. (IMAGE)
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When cells utilize glucose as a carbon source, the HBP functions normally, maintaining intracellular O-GlcNAcylation at a high level. In this state, O-GlcNAc-modified SNAP25 stabilizes its interaction with STX1A and VAMP2, promoting the fusion of MVBs with the plasma membrane and enhancing exosome secretion. In contrast, when cells utilize galactose as a carbon source, HBP activity is suppressed, leading to a significant reduction in intracellular O-GlcNAcylation levels. Consequently, the O-GlcNAc modification of SNAP25 is reduced, preventing the formation of a stable SNARE complex with STX1A and VAMP2, thereby decreasing exosome secretion.
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hLife
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