Mechanism of the combination of different anti-tumor therapies to promote CAR-T cell infiltration (IMAGE)

Chinese Medical Journals Publishing House Co., Ltd.

Mechanism of the combination of different anti-tumor therapies to promote CAR-T cell infiltration

Caption

(Upper left) Chemotherapy promotes CAR-T cell infiltration by enhancing chemokine secretion or degrading the ECM. (Upper right) Radiotherapy promotes CAR-T cell infiltration by improving vascular normalization, inducing immunogenic cell death, enhancing chemokine secretion, and activating endogenous immunity. (Lower right) OVs promote CAR-T cells’ infiltration by expressing chemokines or activating endogenous immunity. (Lower left) PARPi promotes CAR-T cell infiltration via activation of the cGAS-STING pathway.

APC: Antigen-presenting cell; cGAS: Cyclic GMP-AMP synthase; cGAMP: Cyclic GMP-AMP; CAR-T: Chimeric antigen receptor T; dsDNA: Double-stranded DNA; ECM: Extracellular matrix; STING: Simulator of interferon genes; TBK1: TANK-binding kinase 1; IRF3: Interferon regulatory factor 3. OV: Oncolytic virus; PARPi: Polyadenosine diphosphate ribose polymerase inhibitor

Credit

Dr. Yongzhan Nie from the State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, China Image Source Link: https://journals.lww.com/cmj/fulltext/2025/10050/strategies_and_challenges_in_promoting_chimeric.4.aspx

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