Photochemical macrolactonization: A route to brominated intermediates for 7–21-membered lactone rings (IMAGE)
Caption
A new photochemical strategy enables direct macrolactone formation from hydroxyaldehydes through light-activated C–H bromination, generating versatile intermediates for constructing 7–21-membered lactones. The approach offers a milder and more efficient alternative to traditional large-ring synthesis.
Credit
Kenta Tanaka from Okayama University https://pubs.acs.org/doi/10.1021/prechem.5c00095#Abstract
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CC BY-NC-ND