Figure 1. The schematic illustrates the mechanisms governing pluripotency exit, highlighting the pivotal role of PIAS4. By stabilizing KDM5B through SUMOylation, PIAS4 cooperatively modulates H3K4me3 levels at the promoters of pluripotency-associated gene (IMAGE)

KeAi Communications Co., Ltd.

Figure 1. The schematic illustrates the mechanisms governing pluripotency exit, highlighting the pivotal role of PIAS4. By stabilizing KDM5B through SUMOylation, PIAS4 cooperatively modulates H3K4me3 levels at the promoters of pluripotency-associated gene

Caption

Figure 1. The schematic illustrates the mechanisms governing pluripotency exit, highlighting the pivotal role of PIAS4. By stabilizing KDM5B through SUMOylation, PIAS4 cooperatively modulates H3K4me3 levels at the promoters of pluripotency-associated genes (such as LEFTY2 and GNL3L), thereby driving pluripotency exit and cell fate determination.

Credit

Qin W, Wang Y, Duan H F, et al.

Usage Restrictions

Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted.

License

CC BY-NC-ND

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.