Heterogeneity in biological mechanisms of different structural viruses inactivation by various reactive oxygen species (ROS). (IMAGE)

Nanjing Institute of Environmental Sciences, MEE

Heterogeneity in biological mechanisms of different structural viruses inactivation by various reactive oxygen species (ROS).

Caption

Heterogeneity in biological mechanisms of different structural viruses inactivation by various ROS. Schematic illustration of how structurally distinct viruses respond to ROS including hydroxyl radicals (•OH), singlet oxygen (1O2), and superoxide radicals (•O2⁻). Enveloped RNA virus (phi6) exhibits extensive lipid and protein oxidation, while non-enveloped ssRNA (MS2), ssDNA (phix174), and dsDNA (T4) viruses show varying levels of capsid and genome damage. Comparative bars on the right summarize the relative inactivation efficiency and damage intensity of ROS types, revealing that •OH causes the strongest overall inactivation, 1O2 preferentially oxidizes proteins, and •O2⁻ mainly targets RNA.

Credit

Eco-Environment & Health

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