image (IMAGE)
Caption
RSV particles enter the cell through membrane fusion or endocytosis by interacting with host receptors. Following entry, the release and uncoating of the incoming genomic RNA subject it to RNA replication, transcription, and translation with the help of structural proteins. The induction of MMP-9 expression is mediated through NF-κB or AP-1 signaling pathways. MMP-9 cleaves TGM2 and enhances PDI activity, which leads to RSV fusion protein transport to the host cell surface and promotes RSV fusion protein-mediated syncytia formation. This process can be inhibited by JNJ0966, a selective inhibitor of MMP-9, or doxycycline hyclate, a broad-spectrum MMP inhibitor.
Credit
HIGHER EDUCATON PRESS
Usage Restrictions
none
License
Original content