TRPC3 Inhibitor Effectively Suppresses Sustained Atrial Fibrillation in Rats (IMAGE)

Toho University

TRPC3 Inhibitor Effectively Suppresses Sustained Atrial Fibrillation in Rats

Caption

An aorto-venocaval shunt (AVS) produces chronic volume overload for ≥12 weeks, leading to the formation of arrhythmogenic substrates in the rat atria, and the TRPC3 inhibitor pyrazole-3 (Pyr3) effectively suppresses sustained atrial fibrillation. ECG: electrocardiogram, RA: right atrial electrocardiogram, BP: blood pressure

Credit

Dr. Akira Takahara

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