Refining the gut-microbiome axis: A triad of metabolites, targeted microbial delivery, and AI-assisted profiling for precision medicine-food intervention (IMAGE)
Caption
This graphical abstract presents a precision medicine-food paradigm for gut health. Left, a metabolite network (acetate, propionate, lactate, bile acids, polyamines) links the microbiota to immune cells, liver, and barrier function. Center, targeted delivery protects beneficial microbes via microencapsulation and nanocarriers, and enables prebiotic–probiotic co-delivery to boost survival, colonization, and metabolic homeostasis. Right, an AI-profiling module integrates multi-omics and clinical markers to generate a personalized plan (components, dose/timing, target microbes/sites). A closed-loop optimization arrow feeds outcomes back to the AI, guiding iterative refinement. The human silhouette and gut outline unify the three pillars: targeted metabolites, empowered delivery, and AI navigation.
Credit
Food & Medicine Homology, Tsinghua University Press
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