Schematic representation of the VIBV (IMAGE)

Xia & He Publishing Inc.

Schematic representation of the VIBV

Caption

The vector consists of a polyethylene glycolylated liposomal outer coat (providing immune evasion and prolonged circulation), a spindle-shaped nanomotor (resembling a flagellum, facilitating targeted movement), and four distinct internal cargo compartments: (1) miRNA sponge, (2) shRNA, (3) tumor-specific antigen mRNA, and (4) cyclin-inhibitory RNA. These compartments enable multi-step cancer-targeting actions. The approximate length of the spindle-shaped structure is approximately 200 nm. The structure shown is conceptual and illustrates the design framework of the VIBV. miRNA, microRNA; mRNA, messenger RNA; PEG, polyethylene glycol; shRNA, short hairpin RNA; TAA, tumor associated antigen; TSA, tumor specific antigen; VIBV, Vir-inspired Biotechnological Vector.

Credit

Ehsan Nazemalhosseini-Mojarad, Zahra Salehi

Usage Restrictions

Credit must be given to the creator. Only noncommercial uses of the work are permitted.

License

CC BY-NC

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