Schematic of the Cu²⁺-Coordinated Nanoplatform (CuN) and Its Antitumor Mechanism (IMAGE)

Sichuan International Medical Exchange and Promotion Association

Schematic of the Cu²⁺-Coordinated Nanoplatform (CuN) and Its Antitumor Mechanism

Caption

(A) CuN is formed by self-assembly of Cu²⁺ and NLG919 via Cu-N coordination bonds, with chemotherapeutic agents (e.g., β-lapachone) encapsulated through hydrophobic interactions. (B) Lap@CuN passively targets tumors, releases drugs in response to acidic/GSH-rich conditions, generates ROS to induce ICD (CRT exposure, HMGB1 release), and inhibits IDO1 to reverse the ITM—ultimately activating CD8⁺ T cells and suppressing metastasis.

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Shi‐Ying Li

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