MTOC maturation in oocytes (IMAGE)

Science China Press

MTOC maturation in oocytes

Caption

Mechanistic model for MTOC maturation in GV oocytes. The MTOC (grey) activates near the oocyte cortex, which requires recruitment of CKAP5 and TACC3. After activation, MTOC migrates to the nuclear envelope, facilitated by dynein/dynactin. Disrupted MTOC maturation is associated with advanced maternal aging.

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