Characteristics of osteogenesis imperfecta disease in the developed mutant mouse model (IMAGE)

Editorial Office of West China School of Stomatology, Sichuan University

Characteristics of osteogenesis imperfecta disease in the developed mutant mouse model

Caption

By introducing an amino-acid variant at position 342 in the mouse specificity protein 7 (Sp7) gene, researchers have developed an animal model to study osteogenesis imperfecta caused by Sp7 mutation. Increased cortical porosity, lower mineral density, and reduced bone volume fraction was observed in the mutant mice.

Credit

Dr. Jialiang S. Wang and Dr. Marc N. Wein from Harvard Medical School, USA Image Source Link: https://www.nature.com/articles/s41413-025-00440-1

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