Dissecting the functional differences and clinical features of R-spondin family members in metastatic prostate cancer (IMAGE)
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Figure 3: (A) The amino acid sequences are aligned, in which RSPO2 is compared to RSPO1/3/4. Similar (red), dissimilar (yellow), and unique regions (green) are shown. (B) General hydrophobicity of the amino acid side chains of RSPO2 is compared to RSPO1/3/4. The key indicates if a region is hydrophobic (red), hydrophilic (blue), or neutral (grey). (C) Alphafold2 was used to overlay the protein structure of RSPO2 with RSPO1/3/4. The similarity or differences were assessed based on RSMD scores.
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Copyright: © 2025 Deacon et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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