NK cells express inhibitory receptors (TIGIT, PD-1, NKG2A) that tumors exploit to evade immune attack, alongside activating receptors (NKG2D, DNAM-1) that promote cancer cell killing. Blocking inhibitory checkpoints restores anti-tumor function. (IMAGE)

FAR Publishing Limited

NK cells express inhibitory receptors (TIGIT, PD-1, NKG2A) that tumors exploit to evade immune attack, alongside activating receptors (NKG2D, DNAM-1) that promote cancer cell killing. Blocking inhibitory checkpoints restores anti-tumor function.

Caption

NK cells express inhibitory receptors (TIGIT, PD-1, NKG2A) that tumors exploit to evade immune attack, alongside activating receptors (NKG2D, DNAM-1) that promote cancer cell killing. Blocking inhibitory checkpoints restores anti-tumor function.

Credit

Anqi Lin, Pengxi Ye, Zhengrui Li, Aimin Jiang, Zaoqu Liu, Quan Cheng, Jian Zhang, and Peng Luo

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CC BY

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