Regulation of antibody structural dynamics by glycans (IMAGE)

National Institutes of Natural Sciences

Regulation of antibody structural dynamics by glycans

Caption

 (A) Structural propagation pathways originating from galactose residues within the Fc-linked glycan.  (B) Galactose residues (indicated by yellow circles) suppress glycan mobility by acting as molecular anchors, and constrain Fc domain dynamics by serving as molecular wedges—together enhancing the stability of the functional site and promoting effector molecule binding.

Credit

Saeko Yanaka, Koichi Kato

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