Pathological characteristics of perilipin 2-positive lung adenocarcinoma (IMAGE)
Caption
A new study in The American Journal of Pathology suggests that perilipin 2 could serve as a prognostic factor and points to new potential lipid-based targets for treating lung adenocarcinoma. This image depicts histological features of H&E (hematoxylin and eosin) and immunohistochemical staining for perilipin 2 positive lung adenocarcinoma. Perilipin 2 positive adenocarcinomas were associated with poor differentiation (left). Patients with perilipin 2 positive adenocarcinoma had significantly shorter recurrence-free survival times than those who were perilipin 2 negative (middle). In immunofluorescence staining for cancer cell line, lower amount of perilipin 2 expression and lipid droplet accumulation were observed in PLIN2 knockout (KO) cells than in negative control (NC) cells (right).
Credit
The American Journal of Pathology / Miyata-Morita et al.
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CC BY-NC-ND