Refining Single-Atom Catalytic Kinetics for Tumor Homologous-Targeted Catalytic Therapy (IMAGE)
Caption
- Developed a dual-enzyme cascade system integrating iridium single-atom nanozymes with glucose oxidase, optimizing hydrogen peroxide production, acidity, and temperature within the tumor microenvironment to markedly improve catalytic therapy efficacy.
- Functionalized the cascade reaction system with cancer cell membranes to achieve homologous targeting and high biocompatibility, ensuring accurate accumulation at tumor sites while minimizing off-target effects.
Credit
Hengke Liu, Shan Lei, Hongyu Li, Jiayingzi Wu, Ting He, Jing Lin, Peng Huang.
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CC BY-NC-ND