Mechanism of Glyoxalase-Mediated Immune Regulation (IMAGE)
Caption
Researchers reveal how GLO2-SLG Pathway acts as a metabolic brake and regulates inflammation: After immune activation, TTP reduces GLO2 levels, causing SLG to build up in macrophages. SLG then triggers d-lactylation of RelA, a key NF-κB subunit, reducing its ability to activate inflammatory genes and helping to limit excessive immune responses.
Credit
Dr. Huiting Zhou from Children's Hospital of Soochow University, China and Dr. Daolin Tang from UT Southwestern Medical Center, USA Image Source Link: https://www.sciencedirect.com/science/article/pii/S2667100X25000192
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