DLGAP5 mutations disrupt normal chromosome segregation and spindle formation of human oocyte meiosis and lead to female infertilit (IMAGE)

Sichuan International Medical Exchange and Promotion Association

DLGAP5 mutations disrupt normal chromosome segregation and spindle formation of human oocyte meiosis and lead to female infertilit

Caption

DLGAP5 is proposed as a causal gene related to oocyte meiosis disorder for the first time. It expanded the current spectrum of pathogenic genes responsible for the phenotype of oocyte maturation and embryo development defects. It provided a theoretical basis and application values for clinical counseling, genetic diagnosis, and treatment strategies in infertile patients.

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Lei Jin

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