Intracellular metabolite profiling results of PHGDH knockdown. (IMAGE)

China Anti-Cancer Association

Intracellular metabolite profiling results of PHGDH knockdown.

Caption

Intracellular metabolite profiling results of PHGDH knockdown. (A) Heatmap visualization of the distinct metabolic landscapes resulting from PHGDH knockdown. (B) Metabolic pathway enrichment of differential metabolites with MetaboAnalyst (https://www.metaboanalyst.ca). (C–E) Intracellular metabolites, assessed with mass spectrometry after cell transduction with sh-PHGDH. All metabolite levels are normalized to the control. Bar graphs represent the mean ± SD of experimental triplicates (t-test,*P < 0.05,**P < 0.01, ***P < 0.001). (F) Schematic of glutamine metabolism.

Credit

Cancer Biology & Medicine

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CC BY-NC

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