Microglia replacement effectively halts the progression of ALSP in mice and human individuals (IMAGE)
Caption
(Left) Correction of pathogenic Csf1r mutation by Mr BMT effectively rescues pathological changes in the brain, motor impairment and cognitive decline in ALSP mice.
(Right) tBMT-mediated microglia replacement effectively halts disease progression in individuals with ALSP, with preservation of brain integrity, motor performance, and cognitive function.
Credit
Bo Peng and authors
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License
CC BY-NC