Molecular landscape of HER2-mutated non-small cell lung cancer in Northeastern Brazil: Clinical, histopathological, and genomic insights (IMAGE)
Caption
Figure 4: Radiological, histopathological, and molecular features of a HER2 non-amplified lung adenocarcinoma. (A) Chest computed tomography (CT) scan reveals a solid nodular lesion with interspersed cystic areas and a subtle ground-glass halo, exhibiting spiculated margins with pleural impressions, located in the anterior segment of the right upper lobe. (B) Hematoxylin and eosin (H&E) staining shows a mixed acinar and papillary adenocarcinoma pattern, characterized by glandular and papillary structures lined by atypical epithelial cells (scale bar = 100 μm). (C) Immunohistochemistry for HER2 (IHC) demonstrates 1+ membranous staining, indicative of low HER2 expression., with weak incomplete staining in 10% of the tumor (scale bar = 20 μm). (D) Dual in situ hybridization (DISH) indicates a non-amplified HER2 gene status wi (scale bar = 20 μm).
Credit
Copyright: © 2025 Nogueira et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Usage Restrictions
With credit to the original source.
License
Original content