The roles of histone lactylation and non-histone lactylation in cancer (IMAGE)

Sichuan International Medical Exchange and Promotion Association

The roles of histone lactylation and non-histone lactylation in cancer

Caption

Histone Kla regulates tumor angiogenesis by affecting the levels of downstream HIF1-ɑ and Vegf. In non-histone proteins, YY1-Kla influences FGF2, and Sema3A-Kla affects HIF1-ɑ, both contributing to the regulation of angiogenesis in cancer cells. In tumor immunity, histone Kla can impact T cell immune responses, while ALKBH5-Kla, CBX3-Kla, and RIG-I-Kla participate in tumor immunity by modulating the levels of IFN-R, CD47, and NLRP3. In the regulation of cancer cell proliferation, histone Kla affects tumor growth through CDK1, CCNE1, AURK, Cyclin B1, CCR7, IGFBP6, DVOL1, and SDC1, whereas LDHA‐Kla influences breast cancer proliferation

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Juan Du

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