Functions and mechanisms of MRPs family (IMAGE)

Sichuan International Medical Exchange and Promotion Association

Functions and mechanisms of MRPs family

Caption

(A) MRPS29 interacts with ADAR2 and represses A-to-I RNA editing by disrupting the association of ADAR2 with dsRNA, which induces the accumulation of PDZD7WT in cells to promote cancer. (B) MRPL9 upregulates c-MYC to promote the migration of tumors. (C) Exogenous lactate inhibits the expression of MRPL13. The deficiency of MRPL13 induces OXPHOS defect and CLN1 to promote tumor cell invasion. (D) Irradiation increased the expression of MRPL59 which interacts with PKC-δ to promote the phosphorylation of NRF2 and the dissociation of p-NRF2 from KEAP1. Then p-NRF2 translocates into nucleus to activate its target genes and inhibit the aging and apoptosis of BM-MSCs. (E) MRPL59 deficiency induces the induction of Foxp3low Tregs which promote antitumor immunity.

Credit

Dr. Ting Li

Usage Restrictions

Marked by the credited

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.